The Munstermen have lost just twice at home since mid-January with both encounters being in Cork, to Ospreys and Cardiff Blues.
Ospreys have won their last four matches in all tournaments since their 7-9 reversal in Ulster in round 5 of the Guinness PRO12.
The Welshmen have won just two of their last dozen encounters against Irish provinces since May 2015.
The last six meetings between the two sides have been evenly split with three wins apiece, whilst Ospreys have lost on just two of their last six visits to Munster.
Overall Guinness PRO12 head to head record:
Played 29, Munster won 13, Ospreys won 15 with 1 match drawn.
At Irish Independent Park, 7.35pm. Live on TG4 and BBC Wales
Referee: Marius Mitrea (FIR, 57th competition game)
Assistant Referees: Matteo Liperini (FIR), Oisin Quinn (IRFU)
Citing Commissioner: Peter Ferguson (IRFU)
TMO: Carlo Damasco (FIR)
Suite 208, Alexandra House,
Ballsbridge, Dublin 4, Ireland