The Scotsmen's only defeat to an Italian opponent in their last eight such meetings was 11-19 to Zebre in Parma in October 2015.
Zebre are still without a win this season with their most recent victory in the Guinness PRO12 being against Newport Gwent Dragons in Parma in round 22 last season.
The Italians have not been victorious on the road since a trip to Worcester in the European Challenge Cup in January, and have never won in eight previous visits to Scotland.
The five most recent meetings between the two sides have been shaded by Zebre by three wins to two, with all three victories being at Stadio Sergio Lanfranchi.
Overall Guinness PRO12 head to head record:
Played 8, Edinburgh won 5, Zebre won 3.
At BT Murrayfield, 7:35pm.
Referee: Marius Mitrea (FIR, 56th competition game)
Assistant Referees: Emanuele Tomo (FIR), Sam Grove-White (SRU)
Citing Commissioner: Iain Goodall (SRU)
Suite 208, Alexandra House,
Ballsbridge, Dublin 4, Ireland