Zebre won their most recent game in Parma 47-22 against Dragons in round 22 last season but have not won successive matches at the venue since last October.
The reigning Guinness PRO12 Champions, Connacht, have begun the defence of their title with a pair of home defeats, to Glasgow Warriors and Ospreys.
Connacht have not won away from home since beating Edinburgh at BT Murrayfield in early March whilst their only defeat in Italy since October 2013 came on their most recent visit to Treviso in April.
Connacht have a perfect played 12, won 12 record against Zebre in all competitions.
Overall Guinness PRO12 head to head record:
Played 8, Zebre won 0, Connacht won 8.
At Stadio Sergio Lanfranchi, 6.05pm local time (5.05pm Ireland & UK)
Referee: Ian Davies (WRU, 51st competition game)
Assistant Referees: Adam Jones (WRU), Riccardo Angelucci (FIR)
Citing Commissioner: Alberto Recaldini (FIR)
Suite 208, Alexandra House,
Ballsbridge, Dublin 4, Ireland